Floating Alginate Beads as Carriers for Self-Emulsifying System Containing Tetrahydrocurcumin

摘要:

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Tetrahydrocurcumin (THC), one of the curcumin metabolites, exhibits pharmacological activities such as antioxidant, anti-inflammatory and anti-carcinogenic properties. However, the pharmacological effect of THC is limited due to its low aqueous solubility. Floating alginate beads containing self-emulsifying drug delivery system (SEDDS) of THC were developed to increase drug solubility and prolong gastric residence time. Use of different weight proportions of sodium alginate (Na-alg.), calcium chloride (CaCl2) and water soluble pore former (Polyvinylalcohol-polyethylene glycol copolymer; Kollicoat® IR) in bead formulations had different effects on the floating abilities and in vitro rate of THC release. The release profile of the optimized THC-SEDDS floating alginate beads (D3) indicated a significant increase in the dissolution rate of THC and provided a controlled release of THC over an 8 h period in a simulated gastric fluid. The release of about 80% of THC from the optimized beads as an o/w microemulsion with a particle size of less than 50 nm, compared to only 30 % by an aqueous suspension from the unformulated THC could be considerable greater absorbed. The self-emulsifying floating alginate beads may provide a useful solid dosage form for oral delivery of THC and other hydrophobic compounds.

信息:

期刊:

编辑:

Tawee Tunkasiri

页数:

517-520

DOI:

10.4028/www.scientific.net/AMR.506.517

引用:

S. Sriraksa et al., "Floating Alginate Beads as Carriers for Self-Emulsifying System Containing Tetrahydrocurcumin", Advanced Materials Research, Vol. 506, pp. 517-520, 2012

上线时间:

April 2012

输出:

价格:

$35.00

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