In Vivo Biocompatibility of a Novel Ceramic-Metal Biocomposite



An in vivo biocompatibility test of a novel biocomposite, with major phases of CaTiO3 and Ti2O, and minor phases of AlTi3, TiO, CaO and Al2O3, was conducted on rats using subcutaneous implantation. The biocomposite and titanium alloy control specimens were removed at 6 and 14 weeks post-implantation. Histological examination revealed no significant adverse reaction of the surrounding tissue to the either the biocomposite or the control material. We conclude that the composite is well tolerated in a physiological environment.





Panjian Li, Kai Zhang and Clifford W. Colwell, Jr.




D. Ying et al., "In Vivo Biocompatibility of a Novel Ceramic-Metal Biocomposite", Key Engineering Materials, Vols. 284-286, pp. 807-810, 2005


April 2005




[1] T. Kokubo, H.M. Kim, and M. Kawashida, Biomaterials 24(2003), p.2161.

[2] P.K. Chu, J.Y. Chen, L.P. Wang and N Huang, Mat. Sci. and Eng. R 36(2002), p.43.

[3] M. Long and H.J. Rack, Biomaterials 19(1998), p.1621.

[4] D.A. Puleo and A. Nanci, Biomaterials 20 (1999), p.2311.

[5] M. Wang, Biomaterials, 24 (2003), p.2133.

[6] Y.W. Gu, K.A. Khor and P. Cheang, Biomaterials 24 (2003), p.1603.

[7] K.A. Khor, Y.W. Gu, C.H. Quek and P. Cheang, Surface and Coatings Technology 168(2003), p.195.

[8] E. Verne, M. Ferraris and C. Jana, J. European Ceramics Society 19(1999), p. (2039).

[9] E. Verne, M. Ferraris, C. Jana and L. Paracchini, J. European Ceramic Society 20(2000), p.473.

[10] C.Q. Ning and Y. Zhou, Biomaterials 23(2002), p.2909.

[11] LX Luo and DY Ying, A Bio-Composite Made from In Situ Solid State Reaction, 6 th Asian Symposium on Biomaterials, July 2004, China.

[12] Provisional patent NZ 493172.

[13] LX Luo and DY Ying, In-vitro test of a Bio-Composite, 7th World Congress of Biomaterials, May 2004, Sydney.

[14] T. Kodama, Kokubyo Gakkai Zasshi. 1989 Jun 56(2), p.263. (in Japanese).

[15] F.H. Silver and D.L. Christiansen, Biomaterials Science and Biocompatibility, 1999, SpringerVerlag, New York.