New Bioactive Bone Cement Containing Nano-Sized Titania Particles

摘要:

文章预览

Two types of new bioactive polymethylmethacrylate (PMMA)-based bone cements containing nano−sized titania (TiO2) particles were prepared and evaluated to assess the effect of TiO2 content on their mechanical properties and osteoconductivity. We prepared two types of bioactive bone cement, ST50c and ST60c, which contained 50 wt% silanized TiO2 and 60 wt% silanized TiO2, respectively. Commercially available PMMA cement (PMMAc) was used as a control. The cements were inserted into rat tibiae and solidified in situ. After 6 and 12 weeks, they were taken out for evaluation of osteoconductivity by scanning electron microscopy (SEM), contact microradiography (CMR) and Giemsa surface staining. SEM revealed that ST60c and ST50c apposed to bone directly while PMMAc did not. The affinity index of ST60c was significantly higher than for the other cements at each time interval. The results showed that ST60c was a promising material, but its mechanical strength should be improved before application in prosthesis fixation.

信息:

期刊:

主题:

编辑:

Panjian Li, Kai Zhang and Clifford W. Colwell, Jr.

页数:

97-100

DOI:

10.4028/www.scientific.net/KEM.284-286.97

引用:

K. Goto et al., "New Bioactive Bone Cement Containing Nano-Sized Titania Particles", Key Engineering Materials, Vols. 284-286, pp. 97-100, 2005

上线时间:

April 2005

输出:

价格:

$38.00

[1] Freeman MAR, Bradley GW, Ravell PA: J Bone Joint Surg 1982; 64B: 489−493.

[2] Uchida M, Kim H-M, Kokubo T, Fujibayashi S, Nakamura T: J. Biomed. Mater. Res 2003; 64A: 164-170.

[3] Fujibayashi S, Nakamura T, Nishiguchi S, Tamura J, Uchida M, Kim H-M, Kokubo T: J Biomed Mater Res 2001; 56: 562−570.

[4] Nakamura T, Kato H Okada Y, Shinzato S, Kawanabe K, Tamura J, Kokubo T: In: Giannini S, Moroni A, editors. Bioceramics, Vol. 13. Bologna, Italy: Trans Tech; 2000. p.661−664.

为了查看相关信息, 需 Login.