An Implantable Immunosuppressive Cyclosporine Drug Delivery System
In the article a kind biodegradable drug carrier (glycolide-co-lactide-co-caprolactone) tricomponent copolymer (PGLC) was synthesized by ring opening copolymerization of glycolide (GA), lactide (LA) and ε-caprolactone (CL), and was used to manufacture an implantable drug preparation---Cyclosporine-PGLC drug delivery system (Cs-PGLC DDS).The Cs could slowly release from the Cs-PGLC DDS near linearly and last for a long time in vitro. A clinically significant Cs concentration in the cornea and anterior chamber could be achieved by implanting the Cs-PGLC DDS in anterior chamber. It was demonstrated that the Cs-PGLC DDS is a long-effective intraocular immunosuppressive agent for remaining corneal allograft clear and significantly prolong its survival time.
Xingdong Zhang, Junzo Tanaka, Yaoting Yu and Yasuhiko Tabata
S. G. Wang et al., "An Implantable Immunosuppressive Cyclosporine Drug Delivery System", Key Engineering Materials, Vols. 288-289, pp. 125-128, 2005