Mechanical Properties of Living Adherent Cells: Interaction of Cell and Shear Flow

摘要:

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To investigate the interaction of the adherent cell and shear flow, a compound drop model was developed to simulate a living adherent cell adhered to a smooth substrate, and a two dimensional computational fluid dynamics (CFD) was conducted to solve the model equations. The results showed that the deformability of the cell increases with Reynolds number and initial contact angle. The nucleus deforms with the cell, and the deformation index of the cell is greater than that of the nucleus. The cell is more deformable while the nucleus is more capable of resisting external shear flow. The cell and the nucleus are not able to deform infinitely with the increase of Reynolds number and the deformation index reaches a maximum. We conclude that the nucleus plays a particular role in the mechanical properties of the adherent cell.

信息:

期刊:

主题:

编辑:

Xingdong Zhang, Xudong Li, Hongsong Fan, Xuanyong Liu

页数:

1169-1172

引用:

X. H. Liu et al., "Mechanical Properties of Living Adherent Cells: Interaction of Cell and Shear Flow", Key Engineering Materials, Vols. 330-332, pp. 1169-1172, 2007

上线时间:

February 2007

输出:

价格:

$38.00

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[3] 5 0. 0 1. 0 2. 0 3. 0 lg(Re/0. 0005) DI the cell the nucleus 110 130 150 170.

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[4] 0 90 ϕ DI (a) (b) (degree) Fig. 4 Dependence of the deformation indices (DI) on the initial contact angle (ϕ) for the cell and nucleus with N=0. 05 and Re=0. 005. (a) the cell; (b) the nucleus. Fig. 3 Dependence of the deformation indices (DI) on Reynolds number (Re) of the imposed flow with ϕ=150° for the cell and the nucleus.