Biodegradable Porous PCL/HA Scaffolds for Bone Tissue Engineering



Poly ε-caprolactone(PCL)/hydroxyapatite(HA) composite scaffolds were fabricated by particulate leaching and freeze drying routes with different HA content. Porosity was decreased with HA addition, while mean pore size was maintained at around porogen size regardless of HA content. Compressive modulus was increased with increasing HA content. In this study, the optimum content of HA was around 40% in weight against PCL to obtain the highest compressive modulus with keeping porosity above 85%. HA apparently enhanced proliferation of osteoblast-like MG63 cells in PCL/HA composite scaffolds. Typical adhesion, migration and aggregation procedure of MG63 cells were found on PCL, while spreading morphology only was found on HA even at the early stage of adhesion without migration or aggregation.




Young-Ha Kim, Chong-Su Cho, Inn-Kyu Kang, Suk Young Kim and Oh Hyeong Kwon




S. E. Kim et al., "Biodegradable Porous PCL/HA Scaffolds for Bone Tissue Engineering", Key Engineering Materials, Vols. 342-343, pp. 77-80, 2007


July 2007




[1] B.D. Ratner in: Biomaterials Science, edited by B.D. Ratner, A.S. Hoffman, F.J. Schoen and J.E. Lemons, Part I, Academic Press, Amsterdam (2004).

[2] S. V. Bhat : Biomaterials, Chap. 1, Narosa Publishing House, New Delhi (2002).

[3] D.W. Hutmacher : Biomaterials, Vol. 21 (2000) p.2529.

[4] H. Petite, V. Viateau, W. Bensaid, A. Meunier, C. Pollak, M. Bourguignon, K. Oudina, L. Sedel and G. Guillemin : Nature Biotechnology, Vol. 18 (2000) p.959.


[5] L.D. Shea, D. Wang, R.T. Franceschi and D.J. Mooney: Tissue Eng., Vol. 6 (2000) p.605.

[6] J. Rich, T. Jaakkola, T. Tirri, T. Narhi, A. Yli-Urpo and J. Seppala : Biomaterials, Vol. 23 (2002) p.2143.


[7] G. Ciapetti, L. Ambrosio, L. Savarino, D. Granchi, E. Cenni, N. Baldini, S. Pagani, S. Guizzardi, F. Causa and A. Giunti : Biomaterials, Vol. 24 (2003) p.3815.


[8] D.W. Choi, K.G. Marra and P.N. Kumta : Mater. Res. Bull., Vol. 39 (2004) p.417.

[9] V. Guarino, A. Luciani, V. Coccoli, F. Causa, P.A. Netti and L. Ambrosio : 19th European Conference on Biomaterials, Sorrento, Italy, 2005. T304. 20min. 30min. 60min. 240min. 20min. 30min. 60min. 240min . PCL HA.