Biomedical Sensing with Hydroxyapatite Ceramics in GHz Frequency Range



Hydroxyapatite (HA) is a leading biocompatible material extensively used for bone implants as a porous ceramic graft and as a bioactive coating. Electrical characteristics of HA can be employed in implantable devices for real-time in vivo pressure sensor applications such as in knee or hip prosthesis. In particular, high piezo and pyroelectricity of HA, its polarisation by electron beam and selective adsorption of proteins on polarised domains indicate the potential for real-time biosensing applications of HA. For this purpose, a comprehensive understanding of the dielectric behaviour of different forms of HA over a frequency range relevant for biomedical sensing is critical. Such information for HA, especially its frequency dependent dielectric behaviour over the GHz range, is rare. To this end, we report on novel investigations of properties of HA in powder and film forms in the GHz frequency range.




Evangelos Hristoforou and Dr. Dimitros S. Vlachos




O. Korostynska et al., "Biomedical Sensing with Hydroxyapatite Ceramics in GHz Frequency Range", Key Engineering Materials, Vol. 543, pp. 26-29, 2013


March 2013




[1] A. Nagai, K. Yamashita, M. Imamura, and H. Azuma, Hydroxyapatite electret accelerates reendothelialization and attenuates intimal hyperplasia occurring after endothelial removal of the rabbit carotid artery, Life Sciences, vol. 82, pp.1162-1168, Jun (2008).


[2] O. Korostynska, G. Gigilashvili, A. A. Gandhi, and S. A. M. Tofail, High temperature induced pyroelectricity in screen-printed Hydroxyapatite thick films, Proc. ISE-14, 2011, pp.141-142.


[3] S. B. Lang, S. A. M. Tofail, A. A. Gandhi, M. Gregor, C. Wolf-Brandstetter, J. Kost, S. Bauer, and M. Krause, Pyroelectric, piezoelectric, and photoeffects in hydroxyapatite thin films on silicon, Applied Physics Letters, vol. 98, Mar (2011).


[4] S. A. M. Tofail, D. Haverty, F. Cox, J. Erhart, P. Hana, and V. Ryzhenko, Direct and ultrasonic measurements of macroscopic piezoelectricity in sintered hydroxyapatite, Journal of Applied Physics, vol. 105, Mar (2009).


[5] S. A. M. Tofail, C. Baldisserri, D. Haverty, J. B. McMonagle, and J. Erhart, Pyroelectric surface charge in hydroxyapatite ceramics, Journal of Applied Physics, vol. 106, Nov (2009).


[6] D. Haverty, S. A. M. Tofail, K. T. Stanton, and J. B. McMonagle, Structure and stability of hydroxyapatite: Density functional calculation and Rietveld analysis, Physical Review B, vol. 71, Mar (2005).


[7] K. Yamashita, N. Oikawa, and T. Umegaki, Acceleration and Deceleration of Bone-Like Crystal Growth on Ceramic Hydroxyapatite by Electric Poling, Chemistry of Materials, vol. 8, pp.2697-2697, (1996).


[8] C. Ma, A. Nagai, Y. Yamazaki, T. Toyama, Y. Tsutsumi, T. Hanawa, W. Wang, and K. Yamashita, Electrically polarized micro-arc oxidized TiO 2 coatings with enhanced surface hydrophilicity, Acta Biomaterialia, vol. 8, pp.860-865, (2012).


[9] E. Nyfors and P. Vainikainen, Industrial microwave sensors. Norwood: Artech House, (1989).